Fig. 4
From: An integrative approach for building personalized gene regulatory networks for precision medicine
Reconstruction of a gene regulatory network using eQTLs. a SNP rs968567 regulates the interaction between the cis-regulated eQTL gene FADS2 and the sterol binding transcription factor SREBF2 (context-dependent eQTL). b ENCODE ChIP-seq data show that this SNP is located within a SREBF2 binding site, thereby modulating FADS2 gene expression. c Combining the information from cis-eQTL and context-dependent eQTL analysis with ChIP-seq information allows us to decipher how SNP rs968567 modulates the expression of the FADS2 gene. d Combining cis-, trans-, and context-dependent eQTLs or co-expression QTLs has the potential to allow reconstruction of a branch of a gene regulatory network. Parts a–c adapted with permission from Springer Nature, Zhernakova et al. Nature Genetics [29], Copyright 2017. ENCODE Encyclopedia of DNA Elements, eQTL expression quantitative trait locus, SNP single nucleotide polymorphism