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Fig. 3 | Genome Medicine

Fig. 3

From: Next Generation-Targeted Amplicon Sequencing (NG-TAS): an optimised protocol and computational pipeline for cost-effective profiling of circulating tumour DNA

Fig. 3

Detection of SNVs in NA12878 cfDNA dilution series. a Expected versus observed VAF for four SNVs in the NA12878-NA11840 dilution series starting from 50 ng input DNA (left) and zoom-in for expected VAF < 5% (right). b Expected versus observed VAF for four SNVs in the NA12878-NA11840 dilution series starting from 10 ng input DNA (left) and zoom-in for expected VAF < 5% (right). c Expected versus observed VAF for four SNVs in the NA12878-NA11840 dilution series starting from 5 ng input DNA (left) and zoom-in for expected VAF < 5% (right). d Expected versus observed VAF for four SNVs in the NA12878-NA11840 dilution series starting from post-NGS library input DNA (left) and zoom-in for expected VAF < 5% (right)

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Genome Medicine

ISSN: 1756-994X

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