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Table 1 Results of the expression quantitative trait loci-wide association study (eQTLWAS) between genetic variants influencing gene expression and cardiovascular traits in ALSPAC

From: Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

Tag SNP Gene(s) Trait Sample size Beta SE P value
rs646776 SORT1; CELSR2; PSRC1 Total cholesterol 4543 − 0.099 0.016 1.10 × 10−9
rs646776 SORT1; CELSR2; PSRC1 LDL cholesterol 4543 − 0.110 0.015 7.74 × 10−14
rs646776 SORT1; CELSR2; PSRC1 ApoB 4546 − 2.695 0.328 2.66 × 10−16
rs12129500 IL6R IL-6 4503 − 0.126 0.018 4.96 × 10−12
rs11693654 ADCY3; NCOA1; CENPO BMI 6387 0.200 0.036 3.57 × 10−8
rs80026582 LPL Triglycerides 4334 − 0.101 0.018 1.49 × 10−8
rs80026582 LPL VLDL cholesterol 4334 − 0.100 0.018 1.57 × 10−8
rs600038 ABO IL-6 4496 − 0.207 0.021 4.12 × 1022
rs174538 FADS1; FADS2; TMEM258 Total cholesterol 4539 − 0.080 0.015 5.03 × 10−8
rs2727784 APOA1; TAGLN ApoA1 4018 3.047 0.468 8.05 × 10−11
rs10419998 GATAD2A; MAU2; TM6SF2 ApoB 4404 − 2.024 0.376 7.96 × 10−8
  1. Abbreviations for the column headings from left to right: single nucleotide polymorphism, gene or gene cluster associated with SNP, associated trait, sample size for this effect, observed effect size, standard error of the effect size, P value for the observed effect
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Genome Medicine

ISSN: 1756-994X

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