Gene | Case excess | EF (whole gene) | Predictor method | Prioritised variants | Variants not prioritised | ||
---|---|---|---|---|---|---|---|
Case freq. | EF | Case freq. | EF | ||||
MYH7 | 12.76% | 0.930 (0.923–0.938) | HCM cluster | 10.70% | 0.976 (0.972–0.981) | 3.17% | 0.746 (0.706–0.785) |
Consensus | 12.55% | 0.940 (0.933–0.947) | 1.32% | 0.783 (0.728–0.839) | |||
MetaSVM | 12.53% | 0.944 (0.937–0.951) | 1.34% | 0.739 (0.675–0.804) | |||
MetaLR | 13.29% | 0.944 (0.938–0.951) | 0.58% (p = 0.0155) | 0.406 (0.185–0.627) | |||
MYBPC3 | 7.98% | 0.879 (0.865–0.893) | HCM cluster | 2.80% | 0.979 (0.971–0.987) | 6.39% | 0.830 (0.809–0.850) |
Consensus | 8.42% | 0.904 (0.892–0.916) | 0.77% | 0.524 (0.379–0.670) | |||
MetaSVM | 4.27% | 0.945 (0.934–0.957) | 4.92% | 0.811 (0.786–0.837) | |||
MetaLR | 1.78% | 0.900 (0.874–0.925) | 7.41% | 0.871 (0.855–0.887) | |||
TNNT2 | 1.54% | 0.912 (0.889–0.935) | HCM cluster | 1.23% | 0.958 (0.941–0.974) | 0.46% | 0.787 (0.699–0.874) |
Consensus | 1.20% | 0.909 (0.880–0.937) | 0.49% | 0.832 (0.730–0.934) | |||
MetaSVM | 1.11% | 0.894 (0.861–0.927) | 0.58% | 0.905 (0.848–0.961) | |||
MetaLR | 1.11% | 0.889 (0.856–0.923) | 0.58% | 0.921 (0.872–0.971) | |||
TNNI3 | 1.95% | 0.930 (0.912–0.948) | HCM cluster | 1.92% | 0.974 (0.963–0.984) | 0.18% (p = 0.0918) | 0.457 (0.140–0.774) |
Consensus | 1.93% | 0.957 (0.943–0.970) | 0.17% (p = 0.0383) | 0.566 (0.280–0.852) | |||
MetaSVM | 1.77% | 0.939 (0.921–0.957) | 0.33% | 0.873 (0.803–0.944) | |||
MetaLR | 1.87% | 0.932 (0.913–0.951) | 0.23% | 0.903 (0.833–0.973) | |||
MYL3 | 0.70% | 0.833 (0.772–0.895) | HCM cluster | 0.55% | 0.925 (0.886–0.965) | 0.29% (p = 0.0021) | 0.655 (0.455–0.856) |
Consensus | 0.79% | 0.869 (0.817–0.921) | 0.05% (p = 0.6503) | 0.310 (0–1) | |||
MetaSVM | 0.50% | 0.840 (0.763–0.917) | 0.34% | 0.833 (0.735–0.930) | |||
MetaLR | 0.53% | 0.809 (0.722–0.897) | 0.31% | 0.883 (0.809–0.958) | |||
CSRP3 | 0.41% | 0.683 (0.563–0.803) | HCM cluster | 0.43% | 0.882 (0.821–0.943) | 0.16% (p = 0.5533) | 0.158 (0–0.724) |
Consensus | 0.58% | 0.735 (0.630–0.839) | 0.02% (p = 1.0000) | – | |||
MetaSVM | 0.53% | 0.779 (0.687–0.871) | 0.07% (p = 1.0000) | – | |||
MetaLR | 0.55% | 0.751 (0.651–0.852) | 0.05% (p = 1.0000) | – |