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Fig. 2 | Genome Medicine

Fig. 2

From: Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data

Fig. 2

APCST final network. The final PPI network generated from the T2D GWAS interval genes includes 431 seed nodes and 274 linking nodes connected by 2678 interactions. We divided this network into 18 sub-networks (communities) using a community clustering algorithm that maximises network modularity [33], and highlighted enrichment of specific biological processes contained within these based on Gene Ontology terms and REACTOME pathways. Nodes are coloured according to their PCS with grey nodes representing linking nodes. Coloured nodes represent seed nodes, whereas grey nodes represent linking nodes. The size of the nodes is proportional to the network parameter neighbourhood connectivity. These networks are available in cytoscape and edge list format at [https://github.com/jfertaj/T2D_data_integration]

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