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Fig. 4 | Genome Medicine

Fig. 4

From: Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

Fig. 4

Evidence for mutated proteins in the shotgun proteome and database matching. a Annotated spectra of albumin (ALB) showing sequences of wild-type (LAKTYETTLEK; top) and mutated (LAETYETTLEK; bottom) protein measured by LC-MS/MS. b Annotated spectra of RecQ like helicase (RECQL) showing sequences of the peptide AVEIQIQELTER resulting from an additional tryptic cleavage side added directly in front of this sequence through a mutation from histidine to arginine, evidenced in HCC tissue only. c Database matching of natural HLA ligands with wild-type peptide sequence (with diverse HLA restrictions) covering the exact position evidenced as mutated in ALB. d Database matching of natural HLA ligands with wild-type peptide sequence (with diverse HLA restrictions) covering the exact position evidenced as mutated in RECQL

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