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Fig. 5 | Genome Medicine

Fig. 5

From: Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

Fig. 5

Number of database matches of wild-type ligands (WTlig) corresponding to predicted mutated neoepitopes (PNE). PNE with additional evidence in HCC and Mel [24] are highlighted: (1) black: wild-type sequence of PNE contained in database; (2) yellow: wild-type sequence peptide corresponding to PNE confirmed in autologous tissue as natural HLA ligand by mass spectrometry; (3) blue: mutated protein confirmed by shotgun proteomics - PNEprot; (4) red: PNE confirmed as natural HLA ligand by mass spectrometry - NElig

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