From: Discovery and characterization of actionable tumor antigens
TAAs | mTSAs | aeTSAs | |
---|---|---|---|
Genomic origin | Exonic ++++ | Exonic++ Non-exonic ++ | Exonic + (some CGAs) Non-exonic ++++ |
Expression in mTECs/normal tissues | Yes | No | No |
Mutation | No | Yes | No |
Shared among tumors | Often | No/rarely | Often |
Derivation | Overexpression due to genetic and epigenetic changes | Somatic mutations | Epigenetic changes Aberrant splicing |