Fig. 4

CNS Tumor oncoprint of most common Tier 1 and 2 SNVs, idels, and fusions. Summary of most commonly encountered Tier 1 or 2 SNVs and fusion variants identified in > 1 CNS tumor. BRAF fusions and point mutations (V600E) were most common, followed by TP53 and H3F3A hotspot Lys28Met variants. Tumors without BRAF alterations were more likely to have > 1 variant identified per sample, which occurred in 22 tumors. Overall number of clinically significant variants per tumor is represented at the top. The number of variants identified per gene is represented to the right. Age and tumor type are represented across the bottom. CNS = central nervous system, SNV = single nucleotide variant, indel = insertion/deletion