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Fig. 2 | Genome Medicine

Fig. 2

From: Prognostic value of B cells in cutaneous melanoma

Fig. 2

Variation of BCR and TCR measurements across different classifications. a y-axis, −log10(p value) determined using ANOVA separately, for four different classification types: TCGA RNA-seq molecular subtype (keratin-high, immune-high, MITF-low), reg B cell (IL-10± regulatory B cells), BAGS (B cell-associated gene signatures), and TCGA mut (status of BRAFV600/K601, RASG12/G13/Q61, and stop-codon NF1 somatic mutations). Each sub-panel is a different chain type. b Heatmap colored by scaled medians of each measurement across all subtypes. The plot is split into subplots by chain and classification. The medians were scaled across all sub-classifications, together. c Boxplots of selected BCR/TCR repertoire measurements separated by TCGA molecular subtypes split into sub-panels by immunoglobulin chain type. Boxes represent median ± interquartile range and whiskers ±1.5 × interquartile range. Outliers are represented by black dots. Samples included are TCGA SKCM samples with a value for each feature analyzed. See Additional file 2: Table S1

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