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Fig. 1 | Genome Medicine

Fig. 1

From: Somatic mutation and clonal expansions in human tissues

Fig. 1

Mutant cell colonization of healthy esophageal epithelium with age. Each panel is a schematic illustration of a representative 1 cm2 area of normal esophagus from three donors. The younger donor was a moderate smoker and the two older donors were non-smokers. Mutant clones are shown as circles randomly distributed in space. The number of mutant clones and their sizes are directly inferred from the sequencing data, with clone areas being estimated from the fraction of sequencing reads carrying each mutation in each sample (adapted from [3])

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