Skip to main content

Advertisement

Table 1 Summary of mutations included in the curated whole genome drug resistance TBProfiler library

From: Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs

Drug Locus Gene SNPs (No. obs*) Indels (No. obs*)
Rifampicin Rv0667 rpoB 94 (57) 25 (8)
Rv0668 rpoC 8 (8) 0 (0)
Isoniazid Rv1483 fabG1 11 (5) 0 (0)
Rv1484 inhA 13 (6) 0 (0)
Rv1908c katG 226 (78) 37 (9)
Rv2245 kasA 4 (1) 0 (0)
Rv2428 ahpC 21 (10) 0 (0)
Ethambutol Rv1267c embR 20 (3) 0 (0)
Rv3793 embC 25 (4) 0 (0)
Rv3794 embA 9 (5) 6 (0)
Rv3795 embB 127 (52) 1 (0)
Pyrazinamide Rv1630 rpsA 3 (1) 0 (0)
Rv2043c pncA 280 (221) 87 (36)
Rv3601c panD 10 (3) 1 (0)
Streptomycin Rv0682 rpsL 16 (6) 0 (0)
Rv3919c gid 2 (1) 26 (15)
rrs rrs 19 (15) 0 (0)
Ethionamide Rv1483 fabG1 3 (3) 0 (0)
Rv1484 inhA 3 (3) 0 (0)
Rv3854c ethA 33 (23) 42 (39)
Rv3855 ethR 2 (2) 0 (0)
Amikacin rrs rrs 6 (5) 0 (0)
Capreomycin Rv1694 tlyA 16 (2) 13 (2)
rrs rrs 4 (4) 0 (0)
Kanamycin Rv2416c eis 10 (8) 0 (0)
rrs rrs 4 (4) 0 (0)
FQ Rv0005 gyrB 26 (20) 0 (0)
Rv0006 gyrA 21 (17) 0 (0)
PAS Rv2447c folC 18 (10) 0 (0)
Rv2671 ribD 1 (1) 0 (0)
Rv2754c thyX 1 (1) 0 (0)
Rv2764c thyA 19 (9) 5 (0)
Cycloserine Rv2780 ald 0 (0) 12 (10)
Rv3423c alr 3 (3) 0 (0)
Linezolid Rv0701 rplC 1 (1) 0 (0)
rrl rrl 2 (1) 0 (0)
Bedaquiline Rv0678 Rv0678 5 (0) 2 (1)
Clofazimine Rv0678 Rv0678 5 (0) 2 (1)
Delamanid Rv3261 fbiA 1 (0) 0 (0)
  1. Drugs which are new to the library are bolded; indels insertions and deletions, FQ fluoroquinolones, PAS para-aminosalicylic acid. *Number of mutations observed in the ~ 17 k dataset