|
Drug
|
Locus
|
Gene
|
SNPs (No. obs*)
|
Indels (No. obs*)
|
|---|
|
Rifampicin
|
Rv0667
|
rpoB
|
94 (57)
|
25 (8)
|
|
Rv0668
|
rpoC
|
8 (8)
|
0 (0)
|
|
Isoniazid
|
Rv1483
|
fabG1
|
11 (5)
|
0 (0)
|
|
Rv1484
|
inhA
|
13 (6)
|
0 (0)
|
|
Rv1908c
|
katG
|
226 (78)
|
37 (9)
|
|
Rv2245
|
kasA
|
4 (1)
|
0 (0)
|
|
Rv2428
|
ahpC
|
21 (10)
|
0 (0)
|
|
Ethambutol
|
Rv1267c
|
embR
|
20 (3)
|
0 (0)
|
|
Rv3793
|
embC
|
25 (4)
|
0 (0)
|
|
Rv3794
|
embA
|
9 (5)
|
6 (0)
|
|
Rv3795
|
embB
|
127 (52)
|
1 (0)
|
|
Pyrazinamide
|
Rv1630
|
rpsA
|
3 (1)
|
0 (0)
|
|
Rv2043c
|
pncA
|
280 (221)
|
87 (36)
|
|
Rv3601c
|
panD
|
10 (3)
|
1 (0)
|
|
Streptomycin
|
Rv0682
|
rpsL
|
16 (6)
|
0 (0)
|
|
Rv3919c
|
gid
|
2 (1)
|
26 (15)
|
|
rrs
|
rrs
|
19 (15)
|
0 (0)
|
|
Ethionamide
|
Rv1483
|
fabG1
|
3 (3)
|
0 (0)
|
|
Rv1484
|
inhA
|
3 (3)
|
0 (0)
|
|
Rv3854c
|
ethA
|
33 (23)
|
42 (39)
|
|
Rv3855
|
ethR
|
2 (2)
|
0 (0)
|
|
Amikacin
|
rrs
|
rrs
|
6 (5)
|
0 (0)
|
|
Capreomycin
|
Rv1694
|
tlyA
|
16 (2)
|
13 (2)
|
|
rrs
|
rrs
|
4 (4)
|
0 (0)
|
|
Kanamycin
|
Rv2416c
|
eis
|
10 (8)
|
0 (0)
|
|
rrs
|
rrs
|
4 (4)
|
0 (0)
|
|
FQ
|
Rv0005
|
gyrB
|
26 (20)
|
0 (0)
|
|
Rv0006
|
gyrA
|
21 (17)
|
0 (0)
|
|
PAS
|
Rv2447c
|
folC
|
18 (10)
|
0 (0)
|
|
Rv2671
|
ribD
|
1 (1)
|
0 (0)
|
|
Rv2754c
|
thyX
|
1 (1)
|
0 (0)
|
|
Rv2764c
|
thyA
|
19 (9)
|
5 (0)
|
|
Cycloserine
|
Rv2780
|
ald
|
0 (0)
|
12 (10)
|
|
Rv3423c
|
alr
|
3 (3)
|
0 (0)
|
|
Linezolid
|
Rv0701
|
rplC
|
1 (1)
|
0 (0)
|
|
rrl
|
rrl
|
2 (1)
|
0 (0)
|
|
Bedaquiline
|
Rv0678
|
Rv0678
|
5 (0)
|
2 (1)
|
|
Clofazimine
|
Rv0678
|
Rv0678
|
5 (0)
|
2 (1)
|
|
Delamanid
|
Rv3261
|
fbiA
|
1 (0)
|
0 (0)
|
- Drugs which are new to the library are bolded; indels insertions and deletions, FQ fluoroquinolones, PAS para-aminosalicylic acid. *Number of mutations observed in the ~ 17 k dataset
