Table 1 Summary of mutations included in the curated whole genome drug resistance TBProfiler library
Drug | Locus | Gene | SNPs (No. obs*) | Indels (No. obs*) |
|---|---|---|---|---|
Rifampicin | Rv0667 | rpoB | 94 (57) | 25 (8) |
Rv0668 | rpoC | 8 (8) | 0 (0) | |
Isoniazid | Rv1483 | fabG1 | 11 (5) | 0 (0) |
Rv1484 | inhA | 13 (6) | 0 (0) | |
Rv1908c | katG | 226 (78) | 37 (9) | |
Rv2245 | kasA | 4 (1) | 0 (0) | |
Rv2428 | ahpC | 21 (10) | 0 (0) | |
Ethambutol | Rv1267c | embR | 20 (3) | 0 (0) |
Rv3793 | embC | 25 (4) | 0 (0) | |
Rv3794 | embA | 9 (5) | 6 (0) | |
Rv3795 | embB | 127 (52) | 1 (0) | |
Pyrazinamide | Rv1630 | rpsA | 3 (1) | 0 (0) |
Rv2043c | pncA | 280 (221) | 87 (36) | |
Rv3601c | panD | 10 (3) | 1 (0) | |
Streptomycin | Rv0682 | rpsL | 16 (6) | 0 (0) |
Rv3919c | gid | 2 (1) | 26 (15) | |
rrs | rrs | 19 (15) | 0 (0) | |
Ethionamide | Rv1483 | fabG1 | 3 (3) | 0 (0) |
Rv1484 | inhA | 3 (3) | 0 (0) | |
Rv3854c | ethA | 33 (23) | 42 (39) | |
Rv3855 | ethR | 2 (2) | 0 (0) | |
Amikacin | rrs | rrs | 6 (5) | 0 (0) |
Capreomycin | Rv1694 | tlyA | 16 (2) | 13 (2) |
rrs | rrs | 4 (4) | 0 (0) | |
Kanamycin | Rv2416c | eis | 10 (8) | 0 (0) |
rrs | rrs | 4 (4) | 0 (0) | |
FQ | Rv0005 | gyrB | 26 (20) | 0 (0) |
Rv0006 | gyrA | 21 (17) | 0 (0) | |
PAS | Rv2447c | folC | 18 (10) | 0 (0) |
Rv2671 | ribD | 1 (1) | 0 (0) | |
Rv2754c | thyX | 1 (1) | 0 (0) | |
Rv2764c | thyA | 19 (9) | 5 (0) | |
Cycloserine | Rv2780 | ald | 0 (0) | 12 (10) |
Rv3423c | alr | 3 (3) | 0 (0) | |
Linezolid | Rv0701 | rplC | 1 (1) | 0 (0) |
rrl | rrl | 2 (1) | 0 (0) | |
Bedaquiline | Rv0678 | Rv0678 | 5 (0) | 2 (1) |
Clofazimine | Rv0678 | Rv0678 | 5 (0) | 2 (1) |
Delamanid | Rv3261 | fbiA | 1 (0) | 0 (0) |