Fig. 9
From: Evolving neoantigen profiles in colorectal cancers with DNA repair defects
Beta2 microglobulin (B2M) expression is downregulated in EVOLVING-CRC. Transcriptional and protein levels of the B2M gene. a Genes differentially expressed in EVOLVING-CRC relative to STABLE-CRC with a significant p value (p < 0.05). b Waterfall chart showing B2M expression at RNA level across a panel of 45 CRC cell lines. c Western blot analysis of B2M expression. In gray are highlighted samples for which T90 sequencing were not available. Blots were reprobed with anti-HSP90 antibody to confirm equal loading. d B2M gene alterations on 64 CRC cell lines at T0 (upper panel) and codon affected (lower panel)