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Fig. 3 | Genome Medicine

Fig. 3

From: A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases

Fig. 3

Network models of disease-associated cell types. a 24 cell types and subsets that were significantly enriched for GWAS-enriched epigenetic markers associated with RA. Cell type size corresponds to association −ln (p value). b Network model of cell types associated with human rheumatoid arthritis (RA). Nodes correspond to cell types, node size corresponds to significance of association (−log10 RA GWAS-epigenetic marker enrichment p value). Cell types with potential spatial interactions are linked, and cell type position depends on the centrality score as indicated by the rings in the background. c Bar plot of cell type classes ordered by significance of association with 175 human diseases (Fisher combined GWAS-enriched epigenetic markers – disease association p value calculated for each cell type class). d Network model of cell types associated with 175 diseases, based on the same parameters as in b (for details see results)

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