Fig. 4
From: Hidden Markov models lead to higher resolution maps of mutation signature activity in cancer
Enrichment of transition frequencies between mutation signatures in sequence-dependent cloud segments across all samples. a Enrichment represented as Pearson residuals between observed and expected signature frequencies shows a strong enrichment of self-transitions. b Enrichment computed in the same way but ignoring self-transitions to correctly estimate the enrichment of transitions between different signatures while accounting for the enrichment for self-transitions. Mean values of enrichment from random initializations of SIGMA are shown