Table 1 The scoring system of VIC’s automated step
Evidence (scores) | Strong clinical significance | Potential clinical significance | Benign or likely benign | Uncertain significance |
|---|---|---|---|---|
Therapeutic (2/1/0) | 2 | 2/1 | 0 | All other situations |
Mutation type (1/0) | 1 | 1 | 0 | |
Population data (1/0) | 1 | 1 | 0 | |
Somatic data (2/1/0) | 2 | 2/1 | 0 | |
Pathway (2/1/0) | 2 | 2/1 | 0 | |
Germline data (2/1/0) | 2 | > 1* | 1/0 | |
Predictive software (2/1/0) | 2 | 1/0 |