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Table 2 Summary of variant classification in COSMIC and VIC

From: Variant Interpretation for Cancer (VIC): a computational tool for assessing clinical impacts of somatic variants

VIC

COSMIC

Total

Pathogenic

Neutral

None*

Strong significance

6

0

0

6 (0.00%)

Potential significance

14,783

416

567

15,766 (5.78%)

Uncertain significance

158,353

50,026

48,363

256,742 (94.20%)

Benign/likely benign

8

33

5

46 (0.02%)

Total

173,150 (63.53%)

50,475 (18.52%)

48,935 (17.95%)

272,560

  1. *COSMIC variants without “FATHMM_prediction” records in the database