Table 7 Assessment of the lung cancer dataset (100 patients) by VIC, ClinVar, SIFT, PolyPhen-2, and COSMIC. The number of reported variants with strong or potential clinical significance from the diagnostic lab is also listed
VIC | |||||
|---|---|---|---|---|---|
Strong | Potential | Uncertain | Benign/likely benign | Total | |
ClinVar | |||||
Pathogenic | 27 | 58 | 3 | 0 | 88 |
Conflict | 0 | 0 | 0 | 0 | 0 |
Benign | 0 | 0 | 0 | 0 | 0 |
Uncertain | 0 | 1 | 0 | 0 | 1 |
Other | 0 | 1 | 0 | 0 | 1 |
N/A | 0 | 1 | 5 | 0 | 6 |
SIFT | |||||
Damaging | 27 | 40 | 0 | 0 | 67 |
Benign | 0 | 1 | 1 | 0 | 2 |
N/A | 0 | 20 | 7 | 0 | 27 |
PolyPhen-2 | |||||
Damaging | 27 | 33 | 1 | 0 | 61 |
Benign | 0 | 8 | 0 | 0 | 8 |
N/A | 0 | 20 | 7 | 0 | 27 |
COSMIC | |||||
Pathogenic | 27 | 37 | 1 | 0 | 65 |
Neutral | 0 | 0 | 0 | 0 | 0 |
None | 0 | 24 | 5 | 0 | 29 |
N/A | 0 | 0 | 2 | 0 | 2 |
VIC | |||||
Total | 27 | 61 | 8 | 0 | 96 |