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Fig. 2 | Genome Medicine

Fig. 2

From: Identifying chemogenetic interactions from CRISPR screens with drugZ

Fig. 2

Experimental design effects. a–c DrugZ performance across different time points for SUM149PT olaparib screen. a Number of raw hits. b Number of annotated DNA damage response (DDR) genes in hits. c −log P values for DDR gene enrichment. d–f DrugZ performance based on varying number of replicates. d Number of raw hits. e Number of annotated DNA damage response (DDR) genes in hits. f −log P values for DDR gene enrichment. Rep1, 2, 3: all combinations of one, two, or three replicates, ± s.d. Mean: comparing mean of drug-treated samples to the mean of control samples (unpaired approach)

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