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Fig. 3 | Genome Medicine

Fig. 3

From: Identifying chemogenetic interactions from CRISPR screens with drugZ

Fig. 3

DrugZ effectiveness across diverse screens. a–d DrugZ-calculated normZ score is plotted vs. gene rank for SCH772984 screen in four KRAS pancreatic cancer cells cell lines. Synergistic/synthetic lethal (red) and suppressor/resistance (blue) interactions at FDR < 0.1. e Network view of ERK inhibitor screens. Red, synthetic lethal interactions. Blue, suppressor interactions. f–h Glioblastoma cell lines screened for chemogenetic interactions with temozolomide (TMZ), as described in [23]. i Pathway-level summary of modifiers of TMZ activity in glioblastoma cells. j hTERT-RPE1 cells screened for modifiers of vincristine. k Experimental design of CRISPRi/CRISPRa screens for modifiers of rigosertib, as described in [41]. l DrugZ results of the combined rigosertib screens. Red/blue hits are characterized in [41]

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