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Table 1 Description of DNA methylation cohorts

From: Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Cohort1 Sample size2 Number of samples with valid age Mean age (SD) Age range Source Disease
LBC1921 [20, 21] 692 692 82.3 (4.3) [77.8, 90.6] Blood Not available
LBC1936 [20, 21] 2326 2326 72.4 (2.8) [67.7, 77.7] Blood Not available
BSGS [22] 614 614 21.4 (14.1) [9.9, 74.9] Blood Not available
SGPD 1962 1556 67.2 (9.5) [23.0, 104.0] Blood Parkinson’s disease 988, control 974
MND [23] 695 600 45.2 (15.0) [17.0, 76.0] Blood Motor neuron disease (MND) 497, control 198
GS [24, 25] 5101 5100 48.5(14.0) [18.0, 94.5] Blood Not available
GSE72775 [26] 335 335 70.2 (10.3) [36.5, 90.5] Blood Not available
GSE78874 [26] 259 259 68.8(9.7) [36.0, 88.0] Saliva Not available
GSE72773 [26] 310 310 65.6 (13.9) [35.1, 91.9] Blood Not available
GSE72777 [26] 46 46 14.7 (10.4) [2.2, 35.0] Blood Not available
GSE41169 [27] 95 95 31.6 (10.3) [18.0, 65.0] Blood Schizophrenia 62, control 33
GSE40279 [6] 656 656 64.0 (14.7) [19.0, 101.0] Blood Not available
GSE42861 [28] 689 689 51.9 (11.8) [18.0, 70.0] Blood Rheumatoid arthritis 354, control 335
GSE53740 [29] 384 383 67.8(9.6) [34.0, 93.0] Blood Alzheimer’s disease 15, corticobasal degeneration 1, frontotemporal dementia (FTD) 121, FTD/MND 7, progressive supranuclear palsy 43, control 193, unknown 4
  1. 1LBC Lothian Birth Cohort, BSGS Brisbane Systems Genomics Study, SGPD Systems Genomic of Parkinson’s Disease consortium, MND Motor Neuron Disease cohort, GS Generation Scotland. Cohorts with prefix GSE are from the GEO database
  2. 2The number of samples in each cohort. Some samples in LBC were measured from the same individual but at different chronological age