Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Table 1 Description of DNA methylation cohorts

Cohort¹	Sample size²	Number of samples with valid age	Mean age (SD)	Age range	Source	Disease
LBC1921 [20, 21]	692	692	82.3 (4.3)	[77.8, 90.6]	Blood	Not available
LBC1936 [20, 21]	2326	2326	72.4 (2.8)	[67.7, 77.7]	Blood	Not available
BSGS [22]	614	614	21.4 (14.1)	[9.9, 74.9]	Blood	Not available
SGPD	1962	1556	67.2 (9.5)	[23.0, 104.0]	Blood	Parkinson’s disease 988, control 974
MND [23]	695	600	45.2 (15.0)	[17.0, 76.0]	Blood	Motor neuron disease (MND) 497, control 198
GS [24, 25]	5101	5100	48.5(14.0)	[18.0, 94.5]	Blood	Not available
GSE72775 [26]	335	335	70.2 (10.3)	[36.5, 90.5]	Blood	Not available
GSE78874 [26]	259	259	68.8(9.7)	[36.0, 88.0]	Saliva	Not available
GSE72773 [26]	310	310	65.6 (13.9)	[35.1, 91.9]	Blood	Not available
GSE72777 [26]	46	46	14.7 (10.4)	[2.2, 35.0]	Blood	Not available
GSE41169 [27]	95	95	31.6 (10.3)	[18.0, 65.0]	Blood	Schizophrenia 62, control 33
GSE40279 [6]	656	656	64.0 (14.7)	[19.0, 101.0]	Blood	Not available
GSE42861 [28]	689	689	51.9 (11.8)	[18.0, 70.0]	Blood	Rheumatoid arthritis 354, control 335
GSE53740 [29]	384	383	67.8(9.6)	[34.0, 93.0]	Blood	Alzheimer’s disease 15, corticobasal degeneration 1, frontotemporal dementia (FTD) 121, FTD/MND 7, progressive supranuclear palsy 43, control 193, unknown 4

¹LBC Lothian Birth Cohort, BSGS Brisbane Systems Genomics Study, SGPD Systems Genomic of Parkinson’s Disease consortium, MND Motor Neuron Disease cohort, GS Generation Scotland. Cohorts with prefix GSE are from the GEO database
²The number of samples in each cohort. Some samples in LBC were measured from the same individual but at different chronological age

ISSN: 1756-994X