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Table 2 Summary details of two LBC cohorts and the relationship between all-cause mortality and predicted age from different methods (before and after cell count correction)

From: Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

  LBC1921 wave one LBC1936 wave one
N 436 906
N deaths 386 214
Chronological age, mean (SD)1 79.1 (0.6) 69.5 (0.8)
Before cell count correction
 Hannum, mean (SD) 80.3 (6.2) 71.3 (5.7)
 Hannum, hazard ratio (P value, 95% CI)2 1.12 (0.016, 1.02–1.23) 1.18 (0.020, 1.02–1.37)
 Horvath, mean (SD) 73.8 (6.9) 66.1 (6.4)
 Horvath, hazard ratio (P value, 95% CI) 1.09 (0.038, 1.00–1.20) 1.19 (0.0022, 1.06–1.32)
 Elastic Net, mean (SD)3 77.4 (3.6) 72.5 (3.2)
 Elastic Net, hazard ratio (P value, 95% CI) 1.08 (0.38, 0.91–1.27) 1.00 (0.96, 0.79–1.28)
 BLUP, mean (SD)3 77.3 (3.3) 72.5 (2.8)
 BLUP, hazard ratio (P value, 95% CI) 1.20 (0.066, 0.99–1.46) 1.25 (0.12, 0.95–1.64)
After cell count correction
 Hannum, hazard ratio (P value, 95% CI) 1.10 (0.057, 1.00–1.21) 1.11 (0.15, 0.96–1.29)
 Horvath, hazard ratio (P value, 95% CI) 1.07 (0.13, 0.98–1.17) 1.14 (0.032, 1.01–1.28)
 Elastic Net, hazard ratio (P value, 95% CI)3 1.07 (0.39, 0.91–1.27) 1.03 (0.79, 0.82–1.31)
 BLUP, hazard ratio (P value, 95% CI)3 1.21 (0.05, 1.00–1.48) 1.21 (0.17, 0.92–1.60)
  1. 1Mean (predicted) age and its standard deviation
  2. 2Hazard ratio, P value, and 95% confidence interval from the survival analysis based on the predicted age. Hazard ratios were expressed per 5 years of methylation age acceleration
  3. 3Both results of Elastic Net and BLUP were based on the age predictor with the largest training sample size (sample size = 10,411 for LBC1936 and sample size = 12,710 for LBC1921)