Table 2 Summary details of two LBC cohorts and the relationship between all-cause mortality and predicted age from different methods (before and after cell count correction)

N

436

906

N _deaths

386

214

Chronological age, mean (SD)¹

79.1 (0.6)

69.5 (0.8)

 Hannum, mean (SD)

80.3 (6.2)

71.3 (5.7)

 Hannum, hazard ratio (P value, 95% CI)²

1.12 (0.016, 1.02–1.23)

1.18 (0.020, 1.02–1.37)

 Horvath, mean (SD)

73.8 (6.9)

66.1 (6.4)

 Horvath, hazard ratio (P value, 95% CI)

1.09 (0.038, 1.00–1.20)

1.19 (0.0022, 1.06–1.32)

 Elastic Net, mean (SD)³

77.4 (3.6)

72.5 (3.2)

 Elastic Net, hazard ratio (P value, 95% CI)

1.08 (0.38, 0.91–1.27)

1.00 (0.96, 0.79–1.28)

 BLUP, mean (SD)³

77.3 (3.3)

72.5 (2.8)

 BLUP, hazard ratio (P value, 95% CI)

1.20 (0.066, 0.99–1.46)

1.25 (0.12, 0.95–1.64)

 Hannum, hazard ratio (P value, 95% CI)

1.10 (0.057, 1.00–1.21)

1.11 (0.15, 0.96–1.29)

 Horvath, hazard ratio (P value, 95% CI)

1.07 (0.13, 0.98–1.17)

1.14 (0.032, 1.01–1.28)

 Elastic Net, hazard ratio (P value, 95% CI)³

1.07 (0.39, 0.91–1.27)

1.03 (0.79, 0.82–1.31)

 BLUP, hazard ratio (P value, 95% CI)³

1.21 (0.05, 1.00–1.48)

1.21 (0.17, 0.92–1.60)