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Table 3 Enrichment test on the AAR-associated CpG sites from different methods based upon samples from LBC1936 wave one

From: Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

 

Number of significant associations (P < 0.05/319,607)

λ median

Number of CpG sites showing significant cellular heterogeneity

Odds ratio (P value, 95% CI)1

Hannum

12,015

3.6

4958

3.85 (P < 2.2 × 10−16, 3.71–4.00)

Horvath

18,847

5.4

5955

2.53 (P < 2.2 × 10−16, 2.45–2.61)

Elastic Net2

159

2.1

21

0.78 (P = 0.33, 0.47–1.23)

BLUP2

793

2.6

130

1.00 (P = 1.0, 0.82–1.21)

  1. 1The odds ratio for the enrichment of EWAS significant CpG sites in the probe set showing significant cellular heterogeneity
  2. 2Both results of Elastic Net and BLUP were based on the age predictor with the largest training sample size (training set without LBC1936, sample size = 10,411)
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Genome Medicine

ISSN: 1756-994X

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