Fig. 1
From: Identifying Crohn’s disease signal from variome analysis
AVA,Dx pipeline flowchart. A simplified pipeline of AVA,Dx (Analysis of Variation for Association with Disease). Input data is in variant call format (VCF) file from whole exome sequencing. Different versions of gene_scores are calculated as described in the “Methods” section. Models for prediction of Crohn’s disease status are evaluated by cross-validation. Best gene_score scheme, FS algorithm, and, finally, SVM model are selected on the basis of performance in cross-validation. These are further used for prediction of unknown individuals