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Fig. 4 | Genome Medicine

Fig. 4

From: Relating the gut metagenome and metatranscriptome to immunotherapy responses in melanoma patients

Fig. 4

Metagenomic functional pathways related to progression-free survival. For metagenomic pathways selected > 125 times in 500 × 10-fold cross-validated elastic-net penalized Cox regression, that also had FDR-adjusted q < 0.20 and correlated (p < 0.05) metatranscriptomic expression, we show a number of times selected and the hazard ratio (alongside parallel data from the metatranscriptomic analysis in n = 17) and b correlations between metagenomic and metratranscriptomic functional pathway relative abundance. Spearman’s rho and p value are displayed on the plots. c MetaCyc pathway layouts for the pathways in (a, b). Each arrow represents one MetaCyc reaction, color-coded by its hazard ratio in the metagenomic analysis. Arrows in black represent reactions not tested due to low carriage, abundance, or variance of the reaction

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