Fig. 2

Analysis of differentially variable CpG positions (DVPs) in monocytes from patients with sepsis. a Volcano plot showing the p value vs the variance ratio for healthy control, SIRS, and sepsis-associated DVPs. DVPs were identified using the algorithm iEVORA. b Enrichment of sepsis-associated DVPs at 18 distinct chromatin states using ChromHMM. c TF binding motif analysis for sepsis-associated DVPs. Bubbles are colored according to TF family. The p value is indicated by bubble size (selected TF with p ≤ 1e⁻⁰⁷ for DVP regions). d GO categories resulted from GREAT analysis for sepsis-associated DVPs of section (a). e Representative examples showing beta values of DVPs