Fig. 6

Scheme depicting important signaling pathways related to immunity and sepsis. Molecules whose encoding genes displayed DNA methylation alterations in this study are shown in red and blue for hypermethylation and hypomethylation respectively. The following proteins/genes are represented in the figure: TLR, Toll-like receptor; MyD88, myeloid differentiation primary response 88; IRAK, interleukin-1 receptor-associated kinase; IL1R, interleukin-1 receptor; IL-1A, interleukin 1 alpha; TNFR, tumor necrosis factor receptor; TRADD, TNFR1-associated death domain; TRAF, TNF receptor-associated factor; TAK1, transforming growth factor (TGF) beta-activated kinase 1; TAB2, TGF beta-activated kinase 1 binding protein 2; MAPK, mitogen-activated protein kinase; IKK, IκB kinase; AP-1, activator protein 1; NF-кB, nuclear factor kappa B; CCL20, C-C motif chemokine ligand 20; CCL22, C-C motif chemokine ligand 22; IL-23A, interleukin 23A; IL-19, interleukin 19; IL-27, interleukin 27; IL-22, interleukin 22; JAK1, Janus kinase 1; STAT, signal transducer and activator of transcription; TYK2, tyrosine kinase 2; SOCS, suppressor of cytokine signaling. In this scheme, we have selected CpG sites/genes with a minimum 10% of differential of beta values, p < 0.01 and false discovery rate (FDR) < 0.05