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Table 1 Summary of the patient cohorts in the study

From: Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis

  Healthy controls SIRS-cardio patients Septic patients p value (sepsis vs control) p value (sepsis vs SIRS) p value (SIRS vs control)
N 11 4 14    
Age (mean ± SD) 51 ± 11.8 67.8 ± 5.8 74.6 ± 14.5 0.0010*** 0.3662 0.0130**
Sex (% female) 27.3 25 57.1 0.1353 0.2568 0.9299
SOFA 0 3.8 ± 2.2 3.9 ± 2.0 N/A 0.8226 N/A
Basal cytokine levels
 TNFα (pg/ml) (mean ± SD) 9.0 ± 17.0 2.7 ± 3.1 561.4 ± 2082.8 0.9774 0.7845 0.7396
 IL6 (pg/ml) (mean ± SD) 11.9 ± 13.1 123.8 ± 101.4 4273.4 ± 10,789.5 0.0002*** 0.7906 0.0050***
 IL10 (pg/ml) (mean ± SD) 5.8 ± 5.1 81.6 ± 41.4 55.6 ± 72.9 0.0005*** 0.1236 0.0050***
  1. p values of continuous data were calculated using Mann-Whitney U test and categorical data were calculated using chi-squared test. Statistically significant tests are represented as **p < 0.01 and ***p < 0.005
  2. These correspond to the basal levels of the cytokines measured in the serum