| |
Healthy controls
|
SIRS-cardio patients
|
Septic patients
|
p value (sepsis vs control)
|
p value (sepsis vs SIRS)
|
p value (SIRS vs control)
|
|---|
|
N
|
11
|
4
|
14
| | | |
|
Age (mean ± SD)
|
51 ± 11.8
|
67.8 ± 5.8
|
74.6 ± 14.5
|
0.0010***
|
0.3662
|
0.0130**
|
|
Sex (% female)
|
27.3
|
25
|
57.1
|
0.1353
|
0.2568
|
0.9299
|
|
SOFA
|
0
|
3.8 ± 2.2
|
3.9 ± 2.0
|
N/A
|
0.8226
|
N/A
|
|
Basal cytokine levels
|
|
TNFα (pg/ml) (mean ± SD)†
|
9.0 ± 17.0
|
2.7 ± 3.1
|
561.4 ± 2082.8
|
0.9774
|
0.7845
|
0.7396
|
|
IL6 (pg/ml) (mean ± SD)†
|
11.9 ± 13.1
|
123.8 ± 101.4
|
4273.4 ± 10,789.5
|
0.0002***
|
0.7906
|
0.0050***
|
|
IL10 (pg/ml) (mean ± SD)†
|
5.8 ± 5.1
|
81.6 ± 41.4
|
55.6 ± 72.9
|
0.0005***
|
0.1236
|
0.0050***
|
- p values of continuous data were calculated using Mann-Whitney U test and categorical data were calculated using chi-squared test. Statistically significant tests are represented as **p < 0.01 and ***p < 0.005
- †These correspond to the basal levels of the cytokines measured in the serum
