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Table 1 Summary of the patient cohorts in the study

From: Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis

 

Healthy controls

SIRS-cardio patients

Septic patients

p value (sepsis vs control)

p value (sepsis vs SIRS)

p value (SIRS vs control)

N

11

4

14

   

Age (mean ± SD)

51 ± 11.8

67.8 ± 5.8

74.6 ± 14.5

0.0010***

0.3662

0.0130**

Sex (% female)

27.3

25

57.1

0.1353

0.2568

0.9299

SOFA

0

3.8 ± 2.2

3.9 ± 2.0

N/A

0.8226

N/A

Basal cytokine levels

 TNFα (pg/ml) (mean ± SD)†

9.0 ± 17.0

2.7 ± 3.1

561.4 ± 2082.8

0.9774

0.7845

0.7396

 IL6 (pg/ml) (mean ± SD)†

11.9 ± 13.1

123.8 ± 101.4

4273.4 ± 10,789.5

0.0002***

0.7906

0.0050***

 IL10 (pg/ml) (mean ± SD)†

5.8 ± 5.1

81.6 ± 41.4

55.6 ± 72.9

0.0005***

0.1236

0.0050***

  1. p values of continuous data were calculated using Mann-Whitney U test and categorical data were calculated using chi-squared test. Statistically significant tests are represented as **p < 0.01 and ***p < 0.005
  2. †These correspond to the basal levels of the cytokines measured in the serum
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Genome Medicine

ISSN: 1756-994X

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