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Fig. 3 | Genome Medicine

Fig. 3

From: pTuneos: prioritizing tumor neoantigens from next-generation sequencing data

Fig. 3

a MSI status showed strong correlation with neoantigen burden and overall neoantigen immunogenicity score while cytolytic activity did not in stomach adenocarcinoma. b Kaplan-Meier estimates of overall survival according to mutation burden, tumor neoantigen burden (TNB), overall tumor neoantigen immunogenicity score (TNS), cytolytic activity, MSI status, and MHC II expression. The median of each value was selected as a cutoff for high vs low separation in all biomarkers except MSI status classified as MSI and MSS groups. c Univariate and multivariate Cox regression survival analyses of TCGA STAD data on different single biomarkers and all. TNB, tumor neoantigen burden; TNS, overall tumor neoantigen immunogenicity score; MSI, microsatellite instability; MSS, microsatellite stability; HR, hazard ratio; CI, confidence interval

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