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Fig. 5 | Genome Medicine

Fig. 5

From: pTuneos: prioritizing tumor neoantigens from next-generation sequencing data

Fig. 5

a Neither lymphocyte nor cytolytic activity showed correlation with neoantigen burden or overall neoantigen immunogenicity score in cutaneous melanoma. b Kaplan-Meier estimates of overall survival according to mutation burden, tumor neoantigen burden (TNB), overall tumor neoantigen immunogenicity score (TNS), cytolytic activity, lymphocyte score, and MHC II expression. The median of each value was selected as a cutoff for high vs low separation in all biomarkers. c Univariate and multivariate Cox regression survival analyses of TCGA SKCM data on different single biomarkers and all. TNB, tumor neoantigen burden; TNS, overall tumor neoantigen immunogenicity score; HR, hazard ratio; CI, confidence interval

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