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Fig. 5 | Genome Medicine

Fig. 5

From: Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores

Fig. 5

Association of lcWGS-calculated GPSs with disease phenotypes in the clinical cohort. lcWGS-calculated GPSCAD was associated with personal history of CAD (OR = 1.589 (1.32–1.92), n = 11,010, p = 1.32 × 10−6). GPSCAD was adjusted for age and sex. lcWGS-calculated GPSBC was associated with personal history of BC (OR = 1.56 (1.45–1.68); n = 8722, p = 1.0 × 10−16). GPSBC was calculated only for females and adjusted for age at menarche. lcWGS-calculated GPSAF was associated with personal history of AF (OR = 1.277 (1.12–1.46); n = 10,303, p = 0.000292). GPSAF was adjusted for age and sex. lcWGS, low coverage whole genome sequencing; GPS, genome-wide polygenic score; CAD, coronary artery disease; BC, breast cancer; AF, atrial fibrillation

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Genome Medicine

ISSN: 1756-994X

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