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Table 2 Summary of PS3/BS3 assay parameter specifications and strength modification recommendations by each Variant Curation Expert Panel (VCEP)

From: Comparative analysis of functional assay evidence use by ClinGen Variant Curation Expert Panels

VCEPReplicationControlsThresholdsValidationPossible PS3 evidence levels
CDH1  Strong, supporting
Hearing Loss  Moderate, supporting
Inherited Cardiomyopathy (MHY7)   Strong
PAH   Strong
PTEN Strong, supporting
RASopathy   Strong