Fig. 5From: Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertensionLocations of rare, predicted deleterious variants in KLK1 (a) and GGCX (b) across the PAH Biobank cohort (n = 2572 cases). Locations are provided within the two-dimensional protein structures. The numbers of variants at each amino acid position are indicated along the y-axes. The vertical gray lines indicate exon borders. D-MIS, predicted damaging missense; LGD, likely gene disrupting (stop-gain, frameshift, splicing)Back to article page