Skip to main content

Table 1 PAH Biobank cohort demographic and hemodynamic data

From: Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension

  All IPAH APAH FPAH Other*
Total (%) 2572 1110 (43.2) 1239 (48.2) 101 (3.9) 122 (4.7)
Age of onset, n (%)
 Child (dx age < 19) 226 (8.8) 94 (8.5) 112 (9.0) 15 (14.9) 5 (4.1)
 Adult (dx age > =19) 2345 (91.2) 1015 (91.4) 1127 (91.0) 86 (85.1) 117 (95.9)
 Mean age 48 ± 19 48 ± 18 49 ± 19 37 ± 15 47 ± 15
Gender, n (%)
 Female 2023 (78.7) 868 (78.2) 996 (80.4) 69 (68.3) 90 (73.8)
 Male 549 (21.3) 242 (21.8) 243 (19.6) 32 (31.7) 32 (26.2)
 Female to male ratio 3.7:1 3.6:1 4.1:1 2.2:1 2.8:1
Ancestry, n (%)
 European 1852 (72) 809 (73.0) 855 (69.0) 89 (88.1) 99 (81.2)
 Hispanic 315 (12.3) 137 (12.3) 156 (12.6) 10 (9.9) 12 (9.8)
 African 292 (11.4) 117 (10.5) 168 (13.6) 1 (1) 6 (4.9)
 East Asian 70 (2.7) 25 (2.2) 41 (3.3) 0 4 (3.3)
 South Asian 28 (1.1) 12 (1.1) 15 (1.2) 1 (1) 0
 Others 15 (0.58) 10 (0.9) 4 (0.3) 0 1 (0.8)
Hemodynamic parameters
 MPAP (mmHg) 50 ± 14 52 ± 14 48 ± 14 58 ± 14 52 ± 13
 MPCW (mmHg) 10 ± 4 10 ± 4 10 ± 4 10 ± 4 11 ± 4
 CO, Fick (L/min) 4.5 ± 1.8 4.5 ± 1.7 4.6 ± 1.9 3.6 ± 1.0 4.2 ± 1.3
 PVR (Woods units) 10.7 ± 7.0 11.2 ± 7.0 10.0 ± 7.1 14.9 ± 6.3 11.0 ± 6.6
 MAP (mmHg) 90 ± 19 91 ± 20 90 ± 19 88 ± 16 94 ± 19
 MAP:MPAP 1.9 ± 0.7 1.9 ± 0.7 2.0 ± 0.7 1.6 ± 0.5 1.9 ± 0.5
  1. Abbreviations: MPAP mean pulmonary arterial pressure, MPCW mean pulmonary capillary wedge pressure, CO cardiac output by Frick’s method, PVR pulmonary vascular resistance, MAP mean arterial pressure
  2. *Other included 110 diet- and toxin-induced PAH, 11 non-familial pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis, and 1 persistent pulmonary hypertension of the newborn