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Fig. 1 | Genome Medicine

Fig. 1

From: Standard operating procedure for curation and clinical interpretation of variants in cancer

Fig. 1

Overview of the CIViC knowledge model for the exploration of existing data (i.e., searching and browsing) and content curation. a The CIViC knowledge model consists of four interconnected levels that contribute to the content within CIViC: Genes (blue), Variants (orange), Evidence (yellow), and Assertions (green). Each broadly defined CIViC Variant is associated with a single gene but can have many lines of evidence linking it to clinical relevance. b CIViC curation typically begins with the submission of an Evidence Item. Creation of an Evidence Item will automatically generate Gene and Variant records in the knowledgebase if they do not already exist. Once submitted, the Evidence Item undergoes evaluation by expert Editors and (if necessary) revision with ultimate rejection or acceptance. Accepted Evidence Items can be used to build Assertions, which are visualized at the Variant-level. Similar cycles of curation and moderation are employed for all curatable entities in CIViC (e.g., Variant Summaries, Coordinates, Assertions)

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