Skip to main content
Fig. 5 | Genome Medicine

Fig. 5

From: Standard operating procedure for curation and clinical interpretation of variants in cancer

Fig. 5

CIViC Assertion development by Assertion Type. CIViC Assertions summarize a collection of Evidence Items which reflect the state of literature for the given variant and disease. a For Assertion Types typically associated with somatic variants (Predictive, Prognostic, or Diagnostic), AMP-ASCO-CAP 2017 guidelines are followed to associate the Assertion with an AMP Tier and Level, which involves consideration of practice guidelines as well as regulatory approvals associated with specific drugs, as well as consideration of available clinical evidence in the absence of explicit regulatory or practice guidelines. b CIViC Predisposing Assertions utilize ACMG-AMP 2015 guidelines to evaluate the 5-tier classification for a variant in a given disease context, which is supported by a collection of CIViC Evidence Items, along with other data. ACMG evidence codes for an Assertion are supplied by a collection of supporting CIViC Evidence Items (e.g., PP1 from co-segregation data available in a specific publication), and additionally are derived from Variant data (e.g., PM2 from population databases such as gnomAD). ACMG evidence codes are then combined at the Assertion level to generate a disease-specific classification for the Assertion

Back to article page