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Table 1 Summary of classification and reclassification from ClinVar (Jan 2016–July 2019)

From: Is ‘likely pathogenic’ really 90% likely? Reclassification data in ClinVar

Starting classification (n)Percentage reclassified (n)Reclassification type (n)Percentage of initial classification groupPercentage of all reclassifications
Pathogenic (63,658)0.17% (110)P → LP (64)58.2%1.4%
P → VUS (41)37.3%0.91%
P → LB (1)0.91%0.02%
P → B (4)3.6%0.09%
Likely pathogenic (36,808)2.16% (796)LP → P (625)78.5%13.9%
LP → VUS (165)20.7%3.7%
LP → LB (4)0.50%0.09%
LP → B (2)0.25%0.04%
Uncertain significance (272,581)0.95% (2584)VUS → P (171)6.6%3.8%
VUS → LP (486)18.8%10.8%
VUS → LB (1586)61.4%35.2%
VUS → B (341)13.2%7.6%
Likely benign (140,779)0.71% (996)LB → P (2)0.20%0.04%
LB → LP (2)0.20%0.04%
LB → VUS (66)6.6%1.5%
LB → B (926)93.0%20.6%
Benign (58,024)0.03% (15)B → P (1)6.7%0.02%
B → LP (3)20.0%0.07%
B → VUS (1)6.7%0.02%
B → LB (10)66.7%0.22%
  1. Abbreviations: B Benign, LB Likely benign, LP Likely pathogenic, P Pathogenic, VUS Variant of uncertain significance