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Table 3 Evidence strength equivalent of odds of pathogenicity

From: Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework

Odds of pathogenicity (OddsPath)Evidence strength equivalent
< 0.053BS3
< 0.23BS3_moderate*
< 0.48BS3_supporting
0.48–2.1Indeterminate
> 2.1PS3_supporting
> 4.3PS3_moderate
> 18.7PS3
> 350PS3_very_strong
  1. *Since there are no moderate strength benign evidence codes included in the Richards et al.’s guidance, moderate level evidence is equivalent to two instances of supporting-level benign evidence [18]