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Table 1 Age, sex, and age-by-sex associations common to discovery and replication cohorts using both linear regression and MOMENT methods. The results shown correspond to the MOMENT output

From: An epigenome-wide association study of sex-specific chronological ageing

Probe

Chr

BP

Gene

Orientation

Discovery b

Discovery se

Discovery p

Replication b

Replication se

Replication p

Phenotype

cg08097417

7

130,419,133

KLF14

–

4.26

0.40

5E−27

2.45

0.23

7E−27

Age

cg16867657

6

11,044,877

ELOVL2

+

5.05

0.40

4E−36

4.85

0.27

4E−71

Age

cg10501210

1

207,997,020

NA

+

− 1.90

0.19

3E−23

− 1.20

0.12

4E−23

Age

cg07553761

3

160,167,977

TRIM59

+

1.91

0.33

4E−09

1.25

0.20

1E−10

Age

cg23606718

2

131,513,927

FAM123C

+

2.45

0.32

1E−14

1.83

0.23

1E−15

Age

cg02872546

2

109,741,578

NA

–

− 3.63

0.51

6E−13

− 1.94

0.33

2E−09

Age

cg20351734

X

73,571,783

NA

–

− 6.90

0.63

4E−28

− 5.81

0.44

4E−39

Age

cg15833111

X

49,166,019

GAGE10

+

− 3.60

0.46

3E−15

− 2.41

0.26

3E−21

Age

cg25140188

X

31,087,348

NA

+

− 1.81

0.29

6E−10

− 1.49

0.21

9E−13

Age

cg13466600

X

77,587,444

NA

+

− 6.10

0.71

8E−18

− 3.63

0.46

5E−15

Age

cg05517106

X

135,286,461

FHL1

+

− 2.97

0.49

1E−09

− 2.43

0.36

2E−11

Age

cg11643285

3

16,411,667

RFTN1

+

− 0.09

0.01

2E−19

− 0.16

0.01

5E−122

Sex

cg09516963

12

68,042,445

DYRK2

–

− 0.06

0.01

8E−22

− 0.07

3.91E-3

2E−75

Sex

cg05100634

18

45,457,604

SMAD2

–

− 0.06

0.01

2E−30

− 0.03

4.46E-3

2E−11

Sex

cg10334916

2

241,508,098

RNPEPL1

+

0.03

0.01

2E−08

0.02

3.92E-3

2E−09

Sex

cg16532938

2

164,584,635

FIGN

–

− 0.12

0.02

1E−09

− 0.15

0.01

3E−22

Age-by-sex

cg06072257

1

11,434,636

NA

+

− 0.27

0.04

1E−11

− 0.33

0.04

3E−18

Age-by-sex

cg00531806

4

190,938,709

NA

–

− 0.12

0.02

4E−11

− 0.14

0.02

3E−16

Age-by-sex

cg15833111

X

49,166,019

GAGE10

+

0.22

0.02

1E−23

0.14

0.01

6E−27

Age-by-sex

cg05548968

X

30,928,416

NA

–

0.14

0.02

4E−14

0.08

0.01

5E−09

Age-by-sex

cg15475625

X

9,042,463

NA

–

0.21

0.03

1E−12

0.18

0.02

3E−14

Age-by-sex

cg20202246

X

118,407,296

NA

–

0.21

0.03

7E−13

0.23

0.03

1E−15

Age-by-sex

cg08814148

X

118,407,645

NA

+

0.12

0.02

5E−10

0.13

0.01

8E−18

Age-by-sex

cg24541420

X

135,691,028

NA

–

− 0.16

0.02

1E−15

− 0.12

0.01

4E−16

Age-by-sex