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Fig. 4 | Genome Medicine

Fig. 4

From: Stepwise evolution and convergent recombination underlie the global dissemination of carbapenemase-producing Escherichia coli

Fig. 4

Phylogeny and mutations in non-redundant CP-Ec isolates of ST167, ST101, and ST156. ML phylogenies were estimated as for Fig. 1, using 4928, 17,146, and 13,481 non-recombinant SNPs for a Ec ST167, rooted with the ST10 strain MG1655 (NC_00913). The clade enriched in CP-Ec and defined by a mutation in an OmpR box within the ompF promoter region is indicated in red b Ec ST101 and c Ec ST156, respectively, both rooted with the ST1128 strain IAI1 (NC_011741). Branch tips indicate the presence and the type of carbapenemase according to the figure key on the left. On the right side of the tree, the following are represented from left to right: blaCTX-M ESBL, gyrA and parC QRDR mutations, mutations in the ftsI gene, and genetic events affecting ompF and ompC according to the figure key at the bottom. SNPs in the dcw region are represented by small vertical red bars. Genes from the dcw locus are indicated by arrows and the ftsI gene in red. Black arrowheads indicate isolates used as a reference for SNPs mapping in the dcw gene cluster

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