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Table 3 Notable iuc-positive STs by region

From: Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia

Location

Total iuc+

Notable clone/s

iuc allele

N iuc (% of iuc/site)

ICEKp (N)

iro allele (N)

rmpA/2 (N)

ESBL/CP (N)

Hong Kong

6 (22%)

ST45

iuc3

1 (17%)

ICEKp4 (1)

CTX-M-3 (1)

Vietnam

34 (43%)

* ST23

iuc1

13 (38%)

ICEKp10a (10)

ICEKp3 (1)

iro1 (13)

(10)

CTX-M-14 (1)

* ST25

iuc3

2 (6%)

ICEKp1 (2)

iro3 (2)

(2)

iuc1

1 (3%)

iro1 (1)

(1)

* ST65

iuc1

2 (6%)

ICEKp10 a (1)

iro1 (2)

(2)

CTX-M-15, VEB-1 (1)

Thailand

0

 

Laos

23 (38%)

* ST23

iuc1

10 (44%)

ICEKp10 a (10)

iro1 (10)

(10)

CTX-M-63 (1)

* ST65

iuc1

2 (6%)

ICEKp10 a (2)

iro1 (3)

(3)

* ST86

iuc1

ICEKp4 (1)

iro1 (3)

(3)

ST592

iuc1

10 (44%)

iro1 (3)

(3)

Cambodia

4 (10%)

Nepal

3 (9%)

ST15

iuc1

2 (67%)

ICEKp12 (2)

(2)

CTX-M-15 (2)

OXA-232 (1)

India

24 (28%)

ST231

iuc5

12 (50%)

ICEKp5 (12)

CTX-M-15 (8)

OXA-232 (8)

iuc ukn

2 (8%)

ICEKp5 (2)

CTX-M-15 (2)

OXA-232 (2)

ST2096

iuc1

3 (13%)

ICEKp5 (2)

iro1 (1)

CTX-M-15 (2)

* ST23

iuc1

2 (8%)

ICEKp3 (1)

ICEKp10 a (1)

iro1 (2)

(1)

CTX-M-15 (1)

ST11

iuc1

1 (48%)

ICEKp12 (1)

CTX-M-15,

OXA-232 (1)

  1. Total iuc+: total number of genomes carrying iuc per site (i.e. predicted as aerobactin-producing)
  2. Notable clones: clones with ≥ 3 iuc-positive genomes at any single site, or carrying iuc in addition to ESBL and/or carbapenemase genes. *Known hypervirulent STs
  3. iuc allele: iuc lineages predicted by Kleborate. unk = iuc lineage unknown
  4. N iuc: number of genomes of each notable clone carrying iuc per site
  5. ICEKp: ICEKp variants and the number of genomes of notable clones carrying these variants per site. aICEKp10 carries ybt and clb
  6. iro allele: iro lineage and the number of genomes of notable clones carrying these iro variants per site
  7. rmpA/2: number of genomes of notable clones carrying the rmpA and/or rmpA2 loci per site
  8. ESBL/CP: ESBL and carbapenemase genes detected among notable clones and the number of genomes carrying these genes per site