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Table 4 Novel virulence plasmids sequenced in this study and their host isolate properties

From: Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia

Isolate

Virulence plasmid (accession)

iuc lineage

AMR genes

AMR genes elsewhere in genome

Sample data and chromosomal typing

Size and rep type(s)

2579

Nepal, 2016

ST15, KL112, ICEKp12

p2579_1

(MK649822)

182,805 bp

IncHI1B

iuc1

qnrB1, strA^B, mphA, arr2, sulII^, dfrA14, blaOXA-232, blaCTX-M-15, blaTEM-30^

BA6740

India, 2016

ST11, KL24, ICEKp12

pBA6740_1 (MK649823)

226,590 bp

IncFIB(pQIL), IncFIIK

Iuc1

qnrB1

strA^B, rmtF, mphA, arr2, sulII, blaOXA-232, blaCTX-M-15, blaSHV-11, blaTEM-30^

BA813

India, 2017

ST2096, KL64, ICEKp5

pBA813_1

(MK649825)

273,676 bp

IncFIB(Mar), IncFIB

iuc1

blaCTX-M-15, blaOXA-232, blaTEM-54^, aadA2^, armA, msrE, mphE^, catA1^, sulI, tetD, dfrA12, dfrA14

Sat-2A, sulI, dfrA1, blaOXA-1

BA6201

India, 2017

ST231, KL51, ICEKp5

pBA6201_1 (MK649824)

195,016 bp

IncFIA, IncFIB(pQIL), IncFIIK, IncFII

iuc 1

rmtF, mphA, ermB^, catA1^, arr2

blaCTX-M-15, blaTEM-30^

16114547

Laos, 2016

ST290, KL21

p16114547_1 (MK649829)

187,989 bp

IncFIBK, IncFII

iuc 3

qnrS1, tetA^, blaTEM-30^

blaSHV-26^

1675474

Laos, 2015

ST7-1LV, KL54

p1675474_1 (MK649827)

181,647 bp

IncFIBK, IncFII

iuc 3

catA2^, sulII

qnrS1, tetA^,

blaTEM-30^

1675479

Laos, 2015

ST945-2LV, KL125

p1675479_1 (MK649828)

167,992 bp

IncFIBK, IncFII

iuc 3

strA^B, sulII

tetA

130411–38618

Vietnam, 2011

ST17, KL127

p130411-38,618_1 (MK649826)

241,799 bp

IncFIBK, IncFIIK

iuc3

strA^B, aadA1, cmlA5, floR, arr2^, sulII, tetA, dfrA14, blaOXA-10

 
  1. *rep types as per the PlasmidFinder v2.0 database are shown. All plasmids carried the iuc aerobactin synthesis operon. No plasmids carried the iro or rmpA/rmpA2 virulence loci. Seven virulence plasmids also carried AMR (antimicrobial resistance) genes. Seven host isolates harboured additional AMR genes elsewhere in the genome. ST chromosomal multi-locus sequence type, KL K-locus. ^Inexact match