Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia

Table 5 Multi-country clusters of strains sharing a recent common ancestor

ST	Pairwise SNVs (mean)^a	Locations	Sample ID	Year	ESBL/CP genes	ICEKp	Plasmid-borne virulence loci
ST17	33	Cambodia	COMRU-KPN-BC-2014-21	2014	–	Unk	–
ST17	33	Vietnam	CM3425	2015	–	Unk	–
ST65	37–138^b (89)	Laos	1675485	2015	–	ICEKp10^d	iro1, iuc1, rmpA, rmpA2
		Laos	1675477	2015	–	ICEKp10^d	iro1, iuc1, rmpA, rmpA2
		Laos	16114200	2016	–	–	iro1, iuc1, rmpA, rmpA2
		Cambodia	COMRU-KPN-BC-2015-7	2015	–	ICEKp10^d	iro1, iuc1, rmpA, rmpA2
ST86	69	Vietnam	270210–16361	2010	–	ICEKp4	iro1, iuc1, rmpA, rmpA2
ST86	69	Laos	1623415	2016	–	ICEKp4	iro1, iuc1, rmpA
ST101	73	Cambodia	KPN239	2014	CTX-M-15	–	–
ST101	73	Laos	1690095	2015	CTX-M-15, CTX-M-27	–	–
ST592	70–91 (80)	Laos	1675487	2015	–		iuc1, iro1, rmpA2
		Laos	1675478	2015	–	–	iuc1, iro1, rmpA2
		Vietnam	CM3560	2015	–	–	iuc1, iro1, rmpA2
ST14	82	Hong Kong	V28	2016	–	–	–
ST14	82	India	BA33569	2016	–	–	–
ST15	0–202 (84)^c	Nepal	2427	2016	CTX-M-15, OXA-232, NDM-1	ICEKp12	–
		Nepal	2455	2016	CTX-M-15, OXA-232, NDM-1	–	–
		Nepal	2703	2016	CTX-M-15, OXA-232, NDM-1	–	–
		Nepal	2725	2016	CTX-M-15, OXA-232, NDM-1	–	–
		Nepal	2557	2016	CTX-M-15	–	iuc1, rmpA2
		Nepal	2579	2016	CTX-M-15, OXA-232	–	iuc1, rmpA2
		India	BA12537	2017	CTX-M-15	ICEKp12	–
ST412	86	Laos	16112578	2016	–	–	iuc1, iro1, rmpA, rmpA2
ST412	86	India	BA2641	2017	–	–	iuc1, iro1, rmpA, rmpA2

Genomes were clustered at a threshold of ≤ 100 SNVs (i.e. all members of a cluster differ from at least one other member by fewer than 100 SNVs). Clusters comprising isolates from multiple countries are shown. Unk unknown. ^aPairwise SNV count; for clusters of size > 2 genomes the range and mean are shown. ^bCambodian isolate COMRU-KPN-BC-2015-7 differs from each of the Laos isolates by 67–96 SNVs. ^cIndian isolate BA12537 differs from each of the Nepalese isolates by 81–202 SNVs. ^dICEKp10 carries ybt and clb

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