Fig. 1

Differential gene and ERE expression in healthy and dysplastic bone marrow cells. a Gene and ERE transcripts that are differentially expressed between healthy and untreated dysplastic HSCs were identified by multigroup comparison (q ≤ 0.05). Heatmap of the expression of all the identified genes and EREs and hierarchical clustering of samples according to this expression (left), principal component analysis (PCA) based on this expression (top right) and heatmap of the expression of selected genes (bottom right). HSCs from all untreated patients from both cohorts are shown. b, c Heatmaps and corresponding PCA plots of gene and ERE expression differentiating CD4⁺ T cells (b) or CD8⁺ T cells (c) isolated from healthy and untreated dysplastic bone marrow aspirates (multigroup comparison, q ≤ 0.05). Only patients from the second cohort are shown, as RNA-seq data from bone marrow T cells from the first cohort are not available