Fig. 2

ERE responsiveness to 5-AZA treatment. a Comparison of total ERE-derived RNA-seq reads before and after 6 cycles of 5-AZA treatment in MDS and CMML bone marrow HSCs, compared with healthy HSCs. Only patients from the second cohort are shown, as the first cohort was not sampled after six treatment cycles, and lines connect the values for a given patient. Patients with a complete response (CR) or treatment failure (FAIL) are also plotted separately. b Comparison of total ERE-derived RNA-seq reads before and after 6 cycles of 5-AZA treatment in a previously published MDS and CMML bone marrow HSC dataset (SRP067631). c Representation of different classes among 5-AZA-responsive elements in our study (left) and in SRP067631 (right) (≥ 2-fold, p ≤ 0.006). d Hierarchically clustered heatmap of 5-AZA-responsive elements in MDS and CMML bone marrow HSCs in our study (left) and in SRP067631 (right) (≥ 2-fold, p ≤ 0.006). Only patients from the second cohort of our study are shown