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Fig. 4 | Genome Medicine

Fig. 4

From: Single-cell transcriptome analysis reveals TOX as a promoting factor for T cell exhaustion and a predictor for anti-PD-1 responses in human cancer

Fig. 4

TOX-dependent regulation of the expression of immune checkpoint (IC) molecules and the production of effector cytokines in the tumor-infiltrating (TI) CD8+ T cells in human non-small cell lung cancer (NSCLC). a The expression level of IC molecules in the TI CD8+ T cells in human NSCLC when TOX has been knocked down. b Production of IFN-γ and TNF-α in the TI CD8+ T cells in human NSCLC when TOX has been knocked down. Each line in the graph indicates data derived from the same tumor tissue of each individual patient. ns, not significant; *P < 0.05; **P < 0.01; ***P < 0.001. All statistical analyses were performed using paired Student’s t test

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Genome Medicine

ISSN: 1756-994X

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