Fig. 1

Somatic variants in Merkel cell carcinoma. a Tumor mutation burden (TMB) for each patient in descending order colored by mutation signature. b Count of gene copy number alterations per patient. c OncoPrint for the top 10 genes with the greatest number of point mutations in this MCC cohort. d Distribution of point mutations in the CDS of RB1 and TP53 from this MCC cohort. Functional domains of p53 and pRB are highlighted by colored boxes. Each type of base substitution is highlight by a different color lollipop and nonsense mutations are indicated by asterisks