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Fig. 2 | Genome Medicine

Fig. 2

From: Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma

Fig. 2

Recurrent copy number variants in MCC. a Representative network analysis clusters of significantly co-modified genes in MCC on chromosomes 1 (red), 6 (yellow), and 10 (blue). b Frequency of amplifications (red) and deletions (blue) for the genes comprising representative CNV clusters and their occurrence in each patient with UV, RB1, and TP53 status clustered by all variants. c Counts of each CNV cluster colored by TMB-low (blue), TMB-intermediate (gray), and TMB-high (red) categories. Clusters that are nearly equivalent between TMB-low and TMB-high (< 2:1 ratio are highlighted by open triangles). The cluster that is more frequent in TMB-low than TMB-high is highlighted by a black-filled triangle. d Kaplan-Meier plot of overall survival stratified by chromosome 6 amplification for all patients. e Kaplan-Meier plot of overall survival stratified by chromosome 6 amplification for primary tumors. fh Analysis of TCGA cancers for the two most abundant CNV clusters (13, 14, and 6, respectively) in MCC

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