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Table 5 Association between patient characteristics and immunosuppression using Fisher’s exact test

From: Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma

 Immunosuppression 
CharacteristicsAll (N = 71)No (N = 61)Yes (N = 10)Fisher’s exact test
p value
Gender
 Female31 (44%)29 (48%)2 (20%)0.17
 Male40 (56%)32 (52%)8 (80%) 
Race
 Black or African American2 (3%)2 (3%)0 (0%)> 0.99
 White69 (97%)59 (97%)10 (100%) 
Age at initial diagnosis, years
 < =7036 (51%)32 (52%)4 (40%)0.51
 > 7035 (49%)29 (48%)6 (60%) 
Initial site
 Head19 (27%)14 (23%)5 (50%)0.39
 LE15 (21%)14 (23%)1 (10%) 
 Trunk23 (32%)21 (34%)2 (20%) 
 UE14 (20%)12 (20%)2 (20%) 
AJCC stage at initial diagnosis
 I19 (27%)16 (26%)3 (30%)0.96
 II10 (14%)9 (15%)1 (10%) 
 III30 (42%)25 (41%)5 (50%) 
 IV12 (17%)11 (18%)1 (10%) 
Prior chemotherapy or radiation
 No53 (75%)46 (75%)7 (70%)0.71
 Yes18 (25%)15 (25%)3 (30%) 
UV
 Negative47 (66%)45 (74%)2 (20%)< 0.01
 Positive24 (34%)16 (26%)8 (80%) 
RB1 status
 Mutant32 (45%)24 (39%)8 (80%)0.04
 Wild type39 (55%)37 (61%)2 (20%) 
TP53 status
 Mutant31 (44%)25 (41%)6 (60%)0.31
 Wild type40 (56%)36 (59%)4 (40%) 
Virus positive or negative
 VN25 (35%)17 (28%)8 (80%)< 0.01
 VP46 (65%)44 (72%)2 (20%)