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Fig. 2 | Genome Medicine

Fig. 2

From: Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumor

Fig. 2

Ectopic CENP-A loading localizations in DAXX-depleted and wild-type SW403 colorectal cancer cell lines from the Nye et al. dataset. a Mis-segregated chromosomes identified by Worrall et al. through single-cell analysis, compared to the LOH chromosomes we define. b, c Chromosome-relative localization of CENP-A peaks that are found in either DAXX-depleted-only regions (b) or peaks that are found in both DAXX-depleted and control cells (c) for both the commonly mis-segregated and normal-segregation chromosomes as identified by Worrall et al. d Depiction of acquired, maintained, and lost CENP-A peaks when SW403 undergo DAXX depletion. e Correlation plots between mis-segregation fractions and size of the centromere (CEN), or the cytobands immediately flanking the centromere (periCEN) on the p-arm or q-arm. f Correlation plots between the number of CENP-A peaks and mis-segregation fractions

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